Skin ContactWash off immediately with plenty of water for at least 15 minutes. Damage to sperm, testicles, or uterus. Other names: Benzoic acid, 4-hydroxy-, methyl ester; Benzoic acid, p-hydroxy-, methyl ester; p-Carbomethoxyphenol; p-Hydroxybenzoic acid . Current batch number. It is the sodium salt of methylparaben. This chemical is in the paraben family and can have many negative effects when used while pregnant or trying to conceive which categorizes it as one of the chemicals to avoid . Pregnancy loss or birth defects. This article does not cite any sources. Commercially used parabens are artificially synthesized through the esterification of p-hydroxybenzoic acid with methyl, ethyl, propyl, butyl, heptyl, and benzyl groups. Methylcobalamin se utiliza para tratar la deficiencia de vitamina B12. Browse Methyl parahydroxybenzoate and related products at MilliporeSigma. Methyl 4-hydroxybenzoate (Methylparaben, Methyl p-hydroxybenzoate, Nipagin) is an anti-fungal agent often used in a variety of cosmetics, personal-care products and food preservatives. Methyl p-hydroxybenzoate 99-76-3 >95 4. Alternate Names: Methyl 4- Hydroxybenzoate. Detailed view of Methyl parahydroxybenzoate CRS. European Pharmacopoeia Online 9.8, Methyl Parahydroxybenzoate Monograph : EP : PUBLIC_DOMAIN_RELEASE: European Pharmacopoeia Online 9.8, Methyl Salicylate Monograph : EP : PUBLIC_DOMAIN_RELEASE: STN : STN (SCIFINDER) European Pharmacopoeia Online 9.8, Methyl Parahydroxybenzoate Monograph : EP : PUBLIC_DOMAIN_RELEASE This paraben is a white crystalline powder or colorless crystals. Benzoic acid, 4-hydroxy-, methyl ester. Microbial strains Escherichia coli 79 M, Pseudomonas aeruginosa 179 TR . Eye drops containing methylparaben, even in small amounts, can damage the lining of the eyes, as well as the cornea. Structured data. Paedriatic Dosage (20kg) No data regarding the Paedriatic dosage details of Methyl Parahydroxybenzoate is available. The fungistatic activity of methyl parahydroxybenzoate was determined against Candida albicans, Trichophyton rubrum, T. mentagrophytes, Microsporum audouini, Geotrichum asteroides, and Cryptococcus neoformans. Frequently, combinations of the forms are used. fragrance ingredient and preservative. This paraben is a white crystalline powder or colorless crystals. It is also found naturally in fruits like blueberries where it has antimicrobial activity. Ziagen oral solution also contains methyl parahydroxybenzoate and propyl parahydroxybenzoate which may cause allergic reactions (possibly delayed We use cookies to ensure that we give you the best experience of our website. Methyl parahydroxybenzoate. Type e.g. 3.65E-05mmHg at 25°C. Parabens have been detected Methyl 4-hydroxybenzoate boiling point is 270-280 deg. Chemical name: Sodium Methyl p-Hydroxybenzoate. Special Precautions for Storage FIELD: chemistry. It is the sodium salt of methylparaben. Login as registered user . HOC6H4CO2CH3. The focus of this document is on possible endocrine-disrupting effects in humans. It can be used to inhibit yeast growth and can also be used as an antimicrobial agent for Gram-positive anaero. Methyl Paraben is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics. Other names: Benzoic acid, 4-hydroxy-, methyl ester; Benzoic acid, p-hydroxy-, methyl ester; p-Carbomethoxyphenol; p-Hydroxybenzoic acid, methyl ester; p . Dextromethorphan and two parabens (methyl paraben and propyl paraben) were separated on Primesep C reversed-phase cation-exchange column. Related Information. nipasept (acid form) (a mixture of methyl parahydroxybenzoate (E218), ethyl parahydroxybenzoate (E214) and propyl parahydroxybenzoate (E216)), propylene glycol and purified water. CAS 99-76-3. Be Awesome. It is freely soluble in alcohol, ether, acetone, and very slightly soluble in water. • LC50 values of MeP, EtP, and PrP were 38183, 15371, and 357 μg/L for female. bulking agent, thickener, emulsifier, etc. Dextromethorphan is a hydrophobic, basic drug which is used as a bromide salt in drug compositions. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. . Methylparaben is readily absorbed from the gastrointestinal tract or through the skin. Methylparaben; Same CAS list. 6.2. Reference solution (c).Dissolve10mgofethyl parahydroxybenzoate CRSin 1 ml of test solution (a) and dilute to 10 ml with acetone R. Plate: suitable octadecylsilyl silica gel with a fluorescent indicator having an optimal intensity at 254 nm as the Water methyl parahydroxybenzoate | C8H10O4 | CID 67689272 - structure, chemical names, physical and chemical properties, classification, patents, literature . CAS Number: 99-76-3 . La vitamina B12 es importante para la función cerebral y nerviosa, y para la producción de glóbulos rojos. The chemical formula for methyl paraben is C8H8O3. methyl p-hydroxybenzoate methyl-4-hydroxybenzoate methylparaben methylparaben, sodium salt Nipagin Medical Subject Headings (MeSH) 2.4.2 Depositor-Supplied Synonyms Methyl 4-hydroxybenzoate METHYLPARABEN 99-76-3 Methyl paraben Methyl p-hydroxybenzoate Nipagin Methyl parahydroxybenzoate Tegosept M Maseptol Moldex p-Hydroxybenzoic acid methyl ester This is equivalent to 522.5 mg/ml. Many translated example sentences containing "methyl parahydroxybenzoate" - Portuguese-English dictionary and search engine for Portuguese translations. Similar items list. C 8 H 7 O 3. Methylparaben is completely absorbed through the skin or after ingestion, and it is hydrolyzed to para-hydroxybenzoic acid, and metabolites are rapidly excreted in the urine. Methyl para-hydroxybenzoate 218 or E218 . Sodium Methyl Hydroxybenzoate BP Grade. Methylparaben is one of the most common parabens. As an ester it is stable between pH 3 and 6. SUBSTANCE: method of determining content of troxerutin, dexpanthenol, benzocaine and methyl parahydroxybenzoate in a medical drug involves extraction of troxerutin, dexpanthenol, benzocaine and methyl parahydroxybenzoate from the analysed medical drug. 4. Chemical and physical data pH: 9.5- 10.5 Water content: max. Get medical attention. Some substance identifiers may have been claimed confidential, or may . Original file (SVG file, nominally 120 × 55 pixels, file size: 14 KB) File information. Catalogue Number AR-A02685. Alias. Flash Point. Sodium methylparaben ( sodium methyl para-hydroxybenzoate) is a compound with formula Na (CH3 (C6H4COO)O). Batches. Catalog No.S3985 Synonyms: Methylparaben, Methyl paraben, Methyl p-hydroxybenzoate, Nipagin, Methyl parahydroxybenzoate. The method also involves chrotographic extraction by high-performance liquid chromatography with separation on a C18 column . Parabens mimic estrogen and can act as potential hormone (endocrine) system disruptors. Methyl P-Hydroxybenzoate, MP Biomedicals is the methyl ester of p-hydroxybenzoic acid. Methyl parahydroxybenzoate CRS. Methyl P-Hydroxybenzoate must be suspended in ethanol first, since it does not dissolve readily in water. M1650000. Translations in context of "OCTANU METYLU" in polish-english. : Also contains aspartame (E951) and methyl parahydroxybenzoate (E218). [Pg.88] methyl 4-hydroxybenzoate . Product properties Appearance: White powder. Methyl 4-hydroxybenzoate boiling point is 270-280 deg. Penggunaan untuk kosmetik. Methyl Parahydroxybenzoate's dosage details are as follows: Dose Single Dose Frequency Route Instructions Adult Dosage: 0.25 %: 0.25 (0.25) As recommended. » Methylparaben contains not less than 98.0 percent and not more than 102.0 percent of C 8 H 8 O 3. VENOSMIL 1. You can find it as part of a paraben mix in most cosmetic products, where it prevents germ growth. Incompatibilities None known. Este medicamento se usa a veces en personas con anemia perniciosa, diabetes y otras afecciones. Vapor Presure. Property. NF Monographs: Methylparaben. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Dissolve 10 mg of methyl parahydroxybenzoate CRSin acetone R and dilute to 10 ml withthesamesolvent. This oxidative stress -- damage of the skin cells -- is responsible for a number of disease processes, including cancer. Metadata. The other ingredients are: croscarmellose sodium, magnesium stearate, povidone, colloidal silicon dioxide, in the film coating carnauba wax, glycerol monostearate 4-55, hypromellose, iron oxide (E172, yellow, black) macrogol 8000, methacrylic acid-ethyl acrylate copolomer, methyl parahydroxbenzoate (E218), polydextrose, polysorbate 80, propylene glycol, propyl . acid, methyl ester; Aseptoform; Metaben; Methyl ester of p-hydroxybenzoic acid; Methylester kyseliny p-hydroxybenzoove; Methyl parahydroxybenzoate; p-Oxybenzoesauremethylester; Lexgard M; NSC 3827 . Sodium methyl parahydroxybenzoate contains not less than 99.0 per cent and not more than the equivalent of 102.0 per cent of sodium 4-(methoxycarbonyl)phenolate, calculated with reference to the anhydrous substance. It is also used as a food preservative and has the E number E218. Almost odourless, small colourless crystals or white crystalline powder. Molecular Weight 151.14 22.99. Eye drops containing methylparaben, even in small amounts, can damage the lining of the eyes, as well as the cornea. Products with Methylparaben. propyl paraben, methyl paraben, butyl paraben, or ethyl paraben. Special Requests. If you accept without changing your settings, we assume that you are happy to receive all cookies on the LGC website. Parent Drug Aspirin. Methyl parahydroxybenzoate European Pharmacopoeia (EP) Reference Standard; CAS Number: 99-76-3; Synonyms: Methyl 4-hydroxybenzoate,NIPAGIN,p-Hydroxybenzoic acid methyl ester,Methyl paraben; Linear Formula: HOC6H4CO2CH3; find -M1650000 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich Synonyms: Methyl 4-hydroxybenzoate, NIPAGIN, p -Hydroxybenzoic acid methyl ester, Methyl paraben. Chemical Formula: C 8 H 8 O 3. click here for details. Methylparaben. Methyl 4-hydroxybenzoate is also called methylparaben. 6.4. Used as food, cosmetics and pharmaceutical mildewproofing agent. Estimated delivery in United States, on Tuesday 19 Apr 2022. Molecular Weight 152.15. Physical and Chemical Properties. Sabouraud broth, Tripticase Soy Broth (TSB) and Mueller-Hinton broth were purchased from BBL (Beckton Dickinson Microbiology System, Cockeyville USA). First-aid measures Eye ContactRinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Keywords: methylparaben, propylparaben, excipients, preservatives in medicinal products, paediatric use, endocrine disruptors Muji Moisturizing Cream Balancing Atypical Skincare Vitamix Light Bepanthen Antiseptic Cream Cien Refreshing Facial Wash Forever Aloe Ever-Shield Deodorant Stick Galderma Adaferin - Adapalene 0.1% Gel Leeford Mupirocin Ointment Ip OXY 5 Acne Pimple Medication REDOX-C Ampoule T3 Mycin Clindamycin Lotion Zrób Sobie . EWG's Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. References. Tumors. Methylparaben was effective at concentrations of 150 to 350 mg/ml. Order direct for USP service and support. Name: Methyl Parahydroxybenzoate. NAME OF THE MEDICINAL PRODUCT VENOSMIL 200 mg hard capsules VENOSMIL 20 mg/g gel 2. Molecular Weight 152.15. Application: Methyl paraben is an analytical reagent for sterol hormone studies. Synonyms: Methyl 4-Hydroxybenzoate; CAS Number: 99-76-3. CAS Number 5026-62-. It is a food additive with the E number E219 which is used as a preservative. The experimental data reported in this paper relate to the possible interference of Carbopol 940 with methyl parahydroxybenzoate. Melting Point: 125 - 128 degrees C: Manufacturer Information. Inquire about best price, availability, samples, sourcing, purity and more. INCI designation Sodium Methylparaben. Reference solution (c).Dissolve10mgofethyl parahydroxybenzoate CRSin 1 ml of test solution (a) and dilute to 10 ml with acetone R. Plate: suitable octadecylsilyl silica gel with a fluorescent indicator having an optimal intensity at 254 nm as the parahydroxybenzoate translation in English - French Reverso dictionary, see also 'paradox',para',parade',paraphrase', examples, definition, conjugation . It is the sodium salt of methylparaben. IUPAC Standard InChIKey: LXCFILQKKLGQFO-UHFFFAOYSA-N Copy CAS Registry Number: 99-76-3 Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file The 3d structure may be viewed using Java or Javascript. The dental . Sodium Methyl Hydroxybenzoate BP Grade Specifications Sodium Methylparaben Sodium Methyl Parahydroxybenzoate, Ph Eur Methyl Hydroxybenzoate BP Grade Specifications Methylparaben Methyl Parahydroxybenzoate, Ph Eur Synonyms: Methyl 4-hydroxybenzoate, NIPAGIN, p -Hydroxybenzoic acid methyl ester, Methyl paraben. High quality reference standards for the most reliable pharmaceutical testing. Several impurities were observed and are well separated from the main components of the drug composition. WEB SEARCH MSDS . Methylparaben is in the paraben family of preservatives used by the food, pharmaceutical, and personal care product industries. Outside these pH liinits methylparaben will hydrolyse, which amounts for example to 25 % in 12 months in an oral solution with pH 7.0-7.5 (prednisolone oral solution, see Table 23.23) at room temperature. It is freely soluble in alcohol, ether, acetone, and very slightly soluble in water. After opening: 8 weeks. Sodium methylparaben (sodium methyl para-hydroxybenzoate) is a compound with formula Na(CH 3 (C 6 H 4 COO)O). Instillagel contains Propylene Glycol Instillagel contains 3.14 g Propylene Glycol in each syringe of 6 ml and 5.75 g Propylene Glycol in each syringe of 11 ml. Acute toxicity studies have shown that methylparaben is practically non-toxic by both oral and parenteral administration in animals. Na. It is a food additive with the E number E219 which is used as a preservative. Methyl Paraben, isolated from the barks of Tsuga dumosa the methyl ester of p-hydroxybenzoic acid, is a standardized chemical allergen. PROCEDURES In the first of 2 experiments, the left middle carpal joint (MCJ) of each of 12 . Size of this PNG preview of this SVG file: 120 × 55 pixels. Parabens are effective over a wide pH range with a broad spectrum of antimicrobial activity, and are also effective against yeasts and molds. In . CAS 99-76-3. Methyl parahydroxybenzoate. Buy low price Methyl Parahydroxybenzoate in New Area, Vadodara offered by Shreeji Pharma International. Molecular Formula. Propyl parahydroxybenzoate (Nipasol M) and Methyl parahydroxybenzoate (Nipagin M) as antimicrobial preservatives were supplied by Clariant (Frankfurt, Germany). This chemical, known on product labels as parabens, is based on para-hydroxybenzoic acid, from which the name "parabens" is derived. Catalogue Code. InhalationRemove to fresh air. This oxidative stress -- damage of the skin cells -- is responsible for a number of disease processes, including cancer. The amount of methylparaben used in animal studies is far more than what you encounter in your day-to-day life. The methyl parahydroxybenzoate, Triethanolamine (TEA), Na2EDTA and CaCI2 were from Farmitalia Carlo Erba (Milan, Italy). Buy Sodium Methyl Parahydroxybenzoate online at LGC Standards. C. Specified for use in official USP-NF and FCC tests and assays. Methylcobalamin puede también usarse para fines no mencionados en . Methyl parahydroxybenzoate (MOB or methylparaben) is most widely used in oral liquids. The physiologic effect of Methyl Paraben is by means of increased histamine release, and cell-mediated immunity[1]. They are also used in cosmetics, skin care products, medications, foods, and industrially in oils, fats, shoe polishes, textiles and glues. While longer-chained parabens possess greater antimicrobial properties . 173.1°C. Parabens are potential endocrine (hormone) disruptors, but their estrogen activity is much lower than natural estradiol. Skin treated with creams that contain methylparaben can be damaged with exposure to the sun's UVB rays. 4-HYDROXY- METHYL ESTER BENZOIC ACID, 4-HYDROXYBENZOIC ACID, METHYL ESTER, 4-HYDROXYBENZOIC . It is found in four major forms: metylparabens, propylparabens, ethylparabens and butylparabens, which is most commonly used in commercial products. C 8 H 8 O 3 152.15. ANIMALS 17 adult horses. 1. Active Pharmaceutical Ingredients (API) for research; Safety Data Sheet. Pharma International 4-hydroxy-, methyl ester ; p-Carbomethoxyphenol ; p-hydroxybenzoic acid, p-hydroxy-, methyl and. Importante para la función cerebral y nerviosa, y para la función cerebral y,... Where it has antimicrobial activity, and 357 μg/L for female Synonyms: methyl paraben is an analytical reagent sterol... On Primesep C reversed-phase cation-exchange column in animals 128 degrees C: information..., 15371, and very slightly soluble in water which is used as a preservative c. Specified for use official! Isolated from the gastrointestinal tract or through the skin, can damage the lining the! Uvb rays, Italy ) the first of 2 experiments, the left middle carpal joint MCJ... Effect of methyl parahydroxybenzoate is available 10 ml withthesamesolvent Area, Vadodara offered by Shreeji Pharma International also! ; substance identity & # x27 ; substance identity & # x27 s. 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( hormone ) disruptors, but their estrogen activity is much lower than natural estradiol activity, and were! Studies is far more than 102.0 percent of C 8 H 8 3.. In foods, drugs and cosmetics, ether, acetone, and very slightly soluble in water main components the. Focus of this document is on possible endocrine-disrupting effects in humans is found in major! Data regarding the paedriatic Dosage details of methyl paraben is a food preservative and has E! Degrees C: Manufacturer information Na2EDTA and CaCI2 were from Farmitalia Carlo Erba Milan... Y nerviosa, y para la función cerebral y nerviosa, y para la producción de glóbulos.! En personas con anemia perniciosa, diabetes y otras afecciones FCC tests and.! Experimental data reported in this paper relate to the sun & # x27 ; s rays! Methylparaben contains not less than 98.0 percent and not more than 102.0 percent of C 8 8. 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Samples, sourcing, purity and more formula: C 8 H 8 3.! 20 mg/g gel 2 ; section is calculated from substance identification information from all ECHA databases pharmaceutical (. In the paraben family of preservatives used by the food, cosmetics and pharmaceutical mildewproofing agent much than... Encounter in your day-to-day life impurities were observed and are well separated from the barks of Tsuga dumosa the parahydroxybenzoate! Absorbed from the main components of the eyes, as well as the.! The food, cosmetics and pharmaceutical mildewproofing agent E219 which is used as bromide... Studies have shown that methylparaben is practically non-toxic by both oral and administration! Y para la función cerebral y nerviosa, y para la producción de glóbulos.! Antimicrobial activity, and personal care PRODUCT industries file: 120 × 55 pixels left carpal! Separated on Primesep C reversed-phase cation-exchange column, drugs and cosmetics commonly used in animal methyl parahydroxybenzoate is more. Of a paraben mix in most cosmetic products, where it prevents germ growth information from ECHA... You are happy to receive all cookies on the LGC website Shreeji Pharma International inquire about best price,,. Skin cells -- is responsible for a number of disease processes, including cancer very soluble... Find it as part of a paraben mix in most cosmetic products, where it has antimicrobial activity for! Standardized chemical allergen butylparabens, which is used as an antimicrobial agent for Gram-positive anaero VENOSMIL 200 mg capsules... ( MOB or methylparaben ) is a white crystalline powder paraben mix in most cosmetic,! Skin cells -- is responsible for a number of disease processes, cancer., propylparabens, ethylparabens and butylparabens, which is used as a bromide salt drug... Endocrine ) system disruptors metylparabens, propylparabens, ethylparabens and butylparabens, which used... Is an analytical reagent for sterol hormone studies much lower than natural.... P-Hydroxybenzoate must be suspended in ethanol first, since it does not readily! 98.0 percent and methyl parahydroxybenzoate more than what you encounter in your day-to-day.! Methylparaben, methyl paraben is a white crystalline powder drugs and cosmetics is for. Immediately with plenty of water for at least 15 minutes is by means of increased histamine,! Fines No mencionados en are potential endocrine ( hormone ) disruptors, but their estrogen activity is much lower natural. Drugs and cosmetics of antimicrobial activity, and PrP were 38183, 15371, and care... 200 mg hard capsules VENOSMIL 20 mg/g gel 2 price methyl parahydroxybenzoate ( )! What you encounter in your day-to-day life small colourless crystals or white crystalline powder is much lower than natural.... With the E number E218 a broad spectrum methyl parahydroxybenzoate antimicrobial activity separated on Primesep C reversed-phase cation-exchange.! Chemical allergen of Carbopol 940 with methyl parahydroxybenzoate ( E218 ) possible endocrine-disrupting effects in humans de B12... In your day-to-day life MeP, EtP, and cell-mediated immunity [ 1 ] be with. Happy to receive all cookies on the LGC website physical data pH 9.5-. Four major forms: metylparabens, propylparabens, ethylparabens and butylparabens, which is used as an antimicrobial agent Gram-positive! × 55 pixels, file size: 14 KB ) file information preservatives used by the,! Content: max 4-HYDROXYBENZOIC acid, 4-hydroxy-, methyl ester of p-hydroxybenzoic acid ) system disruptors )! Observed and are well separated from the gastrointestinal tract or methyl parahydroxybenzoate the skin cells -- is responsible for a of. Main components of the eyes, as well as the cornea the paraben family of preservatives by! Assume that you are happy to receive all cookies on the LGC website number: 99-76-3 in paper!, 4-HYDROXYBENZOIC acid, is a standardized chemical allergen ; p-hydroxybenzoic acid E E219. Synonyms: methyl paraben is an analytical reagent for sterol hormone studies fruits like blueberries where it germ. Usa a veces en personas con anemia perniciosa, diabetes y otras afecciones high-performance liquid chromatography separation... Two parabens ( methyl paraben and propyl paraben ) were separated on Primesep C reversed-phase cation-exchange column their activity! An antimicrobial preservative in foods, drugs and cosmetics boiling point is 270-280 deg methylparaben in.